Results

5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, oocyte maturation ; induced spawning ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 6:46:20 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
Increased, predation ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, serotonin (5-HT) ; Decreased, anxiety ; Decreased, sheltering
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:37:16 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, muscular waves in foot ; Increased, water retention in foot ; Increased, valve movement ; Depletion, energy reserves ; Increased, foot detachment ; Increased, locomotion ; Increased, serotonin (5-HT) ; Increase, predation ; Decline, Population
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:44:08 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Decline, Population ; Increase, cilia movement ; increased mantel display ; Induced parturition ; Decreased, Reproductive Success
  • 1/13/2017 5:23:22 PM
  • 6/10/2017 6:48:18 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; increased mantel display ; Induced parturition
  • 1/13/2017 9:19:04 PM
  • 6/10/2017 6:49:15 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:51:02 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Acetylcholinesterase inhibition leading to acute mortality
Increased, Mortality ; Inhibition, Acetylcholinesterase (AchE) ; Accumulation, Acetylcholine in synapses ; Increased, Atrioventricular block and bradycardia ; Increased, Respiratory distress/arrest ; Induction, Ataxia, paralysis, or hyperactivity ; Decreased, Population trajectory
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:52:50 PM
  • AOP under development
  • 1.3
Source: https://aopwiki.org/
AChE binding leading to population reduction
AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
Peptide Oxidation ; Reproductive failure ; Activation, JNK ; Activation, FOXO ; Inhibition, Wnt pathway ; Defect of Embryogenesis
  • 2/15/2017 9:35:06 AM
  • 6/10/2017 6:56:13 PM
  • EAGMST under review
  • 1.8
Source: https://aopwiki.org/
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
Formation, Pro-mutagenic DNA Adducts ; Increased, Induced Mutations in Critical Genes ; Metabolism of AFB1, Production of Reactive Electrophiles ; Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) ; Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ; Tumorigenesis, Hepatocellular carcinoma
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:33:04 PM
  • EAGMST under review
  • 2.8
Source: https://aopwiki.org/
AhR activation leading to early life stage mortality
Increased, Mortality ; Decreased, Population trajectory ; Activation, AHR ; dimerization, AHR/ARNT ; Increase, COX-2 expression ; Altered, Cardiovascular development/function ; Increase, Mortality
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:57:20 PM
  • EAGMST under review
  • 1.27
Source: https://aopwiki.org/
AhR activation leading to hepatic steatosis
Activation, AHR ; Up Regulation, CD36 ; Accumulation, Triglyceride ; Accumulation, Fatty acid ; Suppression, VLDL secretion ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ; Increased, SCD-1 ; Increased, FA Influx ; Up Regulation, LDLR (low density lipoprotein receptor) ; Increased, LDL uptake ; Up Regulation, CYP1A1 ; Accumulation, Liver lipid ; Up Regulation, SCD-1
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 6:58:31 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
AhR signalling leading to placental vascular disruption
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:00:12 PM
  • AOP under development
  • 1.42
Source: https://aopwiki.org/
AKT2 activation leading to hepatic steatosis
Activation, SREBF1 ; Increased, Liver Steatosis ; systemic inflammation leading to hepatic steatosis ; Activation, AKT2 ; Activtation, SREBP-1c
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:01:13 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Alkylation of DNA in male prebiotic germ cells leading to heritable mutations
  • 8/20/2017 5:22:50 PM
  • 8/21/2017 3:12:46 PM
Source: https://aopwiki.org/
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
Alkylation, DNA ; Increase, Mutations ; N/A, Insufficient or incorrect DNA repair ; Increase, Heritable mutations in offspring
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 2:47:26 PM
  • OECD endorsed (WNT and WPHA)
  • 1.11
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Alkylation of DNA leading to cancer 1
Alkylation, DNA ; Increase, Mutations ; N/A, Insufficient or incorrect DNA repair ; Increase, Cancer
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:20:35 PM
Source: https://aopwiki.org/
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increased, Binding of chemicals to 2u (serum) ; Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) ; Increase, Cytotoxicity (renal tubular cell) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Hyperplasia (renal tubular cells) ; Increase, Adenomas/carcinomas (renal tubular)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:04:21 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Antgonism of NE receptor ; Decreased, Binding of NE to NE receptors on GnRH neurons
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:03:25 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Altered ion channel activity leading impaired heart function
Increased, Mortality ; impaired, ion channels ; Altered, Action Potential ; Increased, cardiac arrthymia
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:05:26 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Activation, Androgen receptor
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:07:02 PM
  • AOP under development
  • 1.26
Source: https://aopwiki.org/
Androgen receptor agonism leading to reproductive dysfunction
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Agonism, Androgen receptor ; Reduction, Testosterone synthesis by ovarian theca cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Gonadotropins, circulating concentrations ; Decrease, Population trajectory
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:29:25 PM
  • EAGMST approved
  • 1.12
Source: https://aopwiki.org/
Androgen receptor agonism leading to reproductive dysfunction
Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction
  • 4/18/2015 2:24:17 PM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
N/A, Androgen receptor, Antagonism ; Alteration, Wnt pathway ; Feminisation or incomplete development, Primary and accessory male sex organs ; Decreased, Transcription of genes by AR ; N/A, Impairment of reproductive capacity
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:18:51 PM
Source: https://aopwiki.org/
Antagonism of the androgen receptor
Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Antagonist binding to PPARα leading to body-weight loss
Binding of antagonist, PPAR alpha ; Decreased, PPARalpha transactivation of gene expression ; Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Decreased, Ketogenesis (production of ketone bodies) ; Not Increased, Circulating Ketone Bodies ; Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids ; Increased, Catabolism of Muscle Protein ; stabilization, PPAR alpha co-repressor ; Decreased, Body Weight
  • 11/29/2016 11:41:15 PM
  • 6/2/2017 3:11:05 PM
  • EAGMST under review
  • 2.3
Source: https://aopwiki.org/
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone ; Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP ; Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin ; Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis ; Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) ; Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) ; Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal ; Hemostasis, Depletion from blood of fully functional carboxylated clotting factors ; Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction ; Osteoporosis and vascular calcification, Bone deterioration ; Impaired recruitment , Population trajectory
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:12:26 PM
  • AOP under development
  • 1.31
Source: https://aopwiki.org/
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, Dopaminergic activity ; Increased, prolactin secretion ; Increased, hyperplasia (mammary gland)
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:11:02 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
Decreased, Ovarian E2 ; Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secrection of FSH from anterior pituitary ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Decrease, E2 blood concentrations at hypothalamus ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:14:42 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
AOP from chemical insult to cell death
Decompartmentalization ; Direct mitochondrial inhibition ; narcosis ; Mitochondrial impairment ; Apoptosis ; Necrosis
  • 2/6/2017 7:58:57 PM
  • 3/8/2017 3:21:33 PM
Source: https://aopwiki.org/
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; impaired, Fertility ; irregularities, ovarian cycle
  • 11/29/2016 11:41:15 PM
  • 3/10/2017 3:37:16 PM
  • EAGMST under review
  • 1.21
Source: https://aopwiki.org/
Aromatase inhibition
Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol ; reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells ; Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation ; Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus ; Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response ; Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons ; Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:34:50 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Aromatase inhibition leading to reproductive dysfunction
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Aromatase
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:03:03 PM
  • OECD endorsed (WNT and WPHA)
  • 1.12
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to embryolethality via cardiotoxicty
Activation, AHR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Impairment, Endothelial network ; reduced dimerization, ARNT/HIF1-alpha ; Increase, Pericardial edema ; reduced production, VEGF ; Increase, Embryolethality
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:36:05 PM
  • EAGMST under review
  • 1.7
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to uroporphyria
Activation, AHR ; Oxidation, Uroporphyrinogen ; Inhibition, UROD ; Accumulation, Highly carboxylated porphyrins ; Induction, CYP1A2/CYP1A5 ; Uroporphyria
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:37:12 PM
  • EAGMST under review
  • 1.7
Source: https://aopwiki.org/
Axonal sodium channel modulation leading to acute mortality
Increased, Mortality ; modulation, sodium channel ; prolonged, Depolarization of neuronal membrane ; Overactivation, Neuronotransmitter release ; Overactivation, muscle contraction ; Increased, Ataxia, paralysis, or hyperactivity
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:38:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
Activation, beta-2 adrenergic receptor ; Increased activity, beta-2 adrenergic receptor ; relaxation, smooth muscle ; Proliferation/Clonal Expansion, smooth muscle ; Hypertrophy/hyperplasia, smooth muscle ; Promotion, mesovarian leiomyomas
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:39:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
N/A, Mitochondrial dysfunction 1 ; N/A, Neuroinflammation ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decreased, Neuronal network function in adult brain
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:20:28 PM
  • OECD endorsed (WNT and WPHA)
  • 1.23
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Binding to SH/selen-proteins can trigger neuroinflammation leading to neurodegeneration
N/A, Neuroinflammation ; N/A, Neurodegeneration ; Binding, SH-/selen-proteins ; N/A, Interferences with SH-/selen-proteins ; Depletion, GSH ; N/A, Oxidative stress ; N/A, Neuronal dysfunction
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:43:25 PM
  • AOP under development
  • 1.13
Source: https://aopwiki.org/
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures
Binding at picrotoxin site, iGABAR chloride channel ; Reduction, Ionotropic GABA receptor chloride channel conductance ; Occurrence, A paroxysmal depolarizing shift ; Reduction, Neuronal synaptic inhibition ; Generation, Amplified excitatory postsynaptic potential (EPSP) ; Occurrence, Epileptic seizure
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:38:10 PM
  • EAGMST under review
  • 1.15
Source: https://aopwiki.org/
Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Calcium-mediated neuronal ROS production and energy imbalance
Inhibition, Ca++ ATPase ; Increase, Ca++ (intracellular) ; Disruption, Mitochondrial electron transport chain ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decreased, Nitric Oxide ; Decreased, Long-term potentiation (LTP) ; Increased, Oxidative damage
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:18:55 PM
Source: https://aopwiki.org/
Chemical binding to tubulin in oocytes leading to aneuploid offspring
Binding, Tubulin ; Depolymerization, Microtubule ; Disorganization, Spindle ; Altered, Meiotic chromosome dynamics ; Altered, Chromosome number ; Increase, Aneuploid offspring
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:20:04 PM
Source: https://aopwiki.org/
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
Inhibition, Bile Salt Export Pump (ABCB11) ; Activation of specific nuclear receptors, Transcriptional change ; Bile accumulation, Pathological condition ; Release, Cytokine ; Increase, Inflammation ; Production, Reactive oxygen species ; Peptide Oxidation ; Cholestasis, Pathology
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:47:48 PM
  • AOP under development
  • 1.19
Source: https://aopwiki.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; Impairment, Learning and memory ; Aberrant, Dendritic morphology ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Reduced, Presynaptic release of glutamate
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:16:28 PM
  • OECD endorsed (WNT and WPHA)
  • 1.22
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment
  • 10/15/2016 9:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
N/A, Neuroinflammation ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:39:12 PM
  • EAGMST under review
  • 1.13
Source: https://aopwiki.org/
Chronic Cyp2E1 Activation Leading to Liver Cancer
Activation of Cyp2E1 in the liver ; Oxidative Stress ; Hepatocytotoxicity ; Hepatocellular Regenerative Proliferation ; Liver Cancer
  • 5/30/2017 5:25:04 PM
  • 6/10/2017 7:49:06 PM
  • AOP under development
  • 1.24
Source: https://aopwiki.org/
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Increase, Cytotoxicity (hepatocytes) ; Increase, Regenerative cell proliferation (hepatocytes)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:50:27 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
Increased, Oxidative Stress ; Increased, secretion of local growth factors ; persistent, cytotoxicity (pleura or peritoneum) ; Increased, inflammation ; Increased, Cell Proliferation (mesothelium) ; Increased, mesotheliomas
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:52:16 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Activation, Constitutive androstane receptor ; Altered gene expression specific to CAR activation, Hepatocytes ; Increase, Preneoplastic foci (hepatocytes)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:53:47 PM
  • AOP under development
  • 1.18
Source: https://aopwiki.org/
Covalent Protein binding leading to Skin Sensitisation
Covalent Binding, Protein ; Activation, Keratinocytes ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; sensitisation, skin
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:22:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.1
  • i-Library
Source: https://aopwiki.org/
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
Increased, Mortality ; Decline, Population ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Inhibition, Cyclooxygenase 1 activity ; Decreased, Prostaglandin F2alpha concentration, plasma ; Occurrence, renal ischemia
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 7:55:17 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading reproductive failure
Inhibition, Cyclooxygenase activity ; Reduction, Prostaglandin E2 concentration ; Reduction, Ca and HCO3 transport to shell gland ; Reduction, Eggshell thickness ; N/A, Gap ; N/A, Reproductive failure
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:56:47 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction
Inhibition, Cyclooxygenase activity ; Decrease, Ovulation ; Reduced, Prostaglandins, ovary ; Reduced, Reproductive Success ; Declining, Population trajectory
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:57:51 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Prostaglandin F2alpha synthesis, ovary ; Reduced, Spawning behavior ; Reduced, Ability to attract spawning mates
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:58:41 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Ability to attract spawning mates ; Reduced, Pheromone release ; Decreased, Prostaglandin F2alpha synthesis, ovary ; Decline, Population trajectory
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 7:59:21 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Decline, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Reduced, Meiotic prophase I/metaphase I transition, oocyte ; Increased, cyclic adenosine monophosphate
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:00:06 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Declining, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Upregulated, Spindle assembly checkpoint protein Mad2-oocyte ; Increased, Chromosome misseggregation
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:00:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
Increase, Cytotoxicity (club cells) ; Increase, Necrosis (terminal bronchiolar cells) ; Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) ; Increase, Hyperplasia (terminal bronchiolar cells) ; Increase, Adenomas/carcinomas (bronchioloalveolar)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:02:32 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increase, Cytotoxicity (tubular epithelial cells) ; Increase, Hyperplasia (tubular epithelial cells)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:03:08 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; impaired, Larval development ; Decreased, Glucose oxidase enzyme activity ; Decreased, Hydrogen peroxide production ; Reduced, Antiseptic incorporated in food ; Reduced, Food storage
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:04:26 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
Decreased, Androgen receptor activity ; Decreased, Testosterone binding to androgen receptor (hypothalamus) ; Increase, Hyperplasia (Leydig cells) ; Increased, Luteinizing hormone (LH) ; Increase, Leydig cell tumors
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:05:39 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:07:32 PM
  • AOP under development
  • 1.35
Source: https://aopwiki.org/
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:08:05 PM
  • AOP under development
  • 1.35
Source: https://aopwiki.org/
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:08:31 PM
  • AOP under development
  • 1.35
Source: https://aopwiki.org/
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:08:56 PM
  • AOP under development
  • 1.35
Source: https://aopwiki.org/
Disruption of VEGFR Signaling Leading to Developmental Defects
Inhibition, VegfR2 ; Reduction, Angiogenesis ; Impairment, Endothelial network ; Insufficiency, Vascular ; Increased, Developmental Defects
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:40:31 PM
  • EAGMST under review
  • 1.6
Source: https://aopwiki.org/
DNA Adducts Leading to Liver Hemangiosarcoma
  • 7/14/2017 5:38:40 PM
  • 7/15/2017 3:12:17 PM
Source: https://aopwiki.org/
DNA Intercalation Mediated Cardiomyopathy
Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Dual oxidase
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:10:47 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
prepubertal increase, Estrogen receptor (ER) activity ; Activation, estrogen receptor alpha ; Promotion, SIX-1 postive basal-type progenitor cells ; Proliferation/Clonal Expansion, aberrant basal cells ; squamous metaplasia, aberrant basal cells ; Increased, Hyperplasia (glandular epithelial cells of endometrium) ; Increased, adenosquamous carcinomas of endometrium
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:12:06 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Ecdysone receptor agonism leading to mortality
Activation, Ecdysone receptor ; Induction, Nuclear receptor E75b gene ; Suppression, Fushi tarazu factor-1 gene ; Reduction, Release of circulating ecdysis triggering hormone ; Reduction, Release of circulating crustacean cardioactive peptide ; Reduction, Ecdysis motoneuron bursts ; Reduction, Excitatory postsynaptic potential ; Reduction, Abdominal muscle contraction ; Induction, Incomplete ecdysis ; Increased, Mortality
  • 11/29/2016 11:41:15 PM
  • 3/8/2017 3:18:37 PM
Source: https://aopwiki.org/
EGFR Activation Leading to Decreased Lung Function
Activation, EGFR ; Occurrence, Transdifferentiation of ciliated epithelial cells ; Occurrence, Metaplasia of goblet cells ; Occurrence, Hyperplasia of goblet cells ; Increase, Proliferation of goblet cells ; Activation, SP1 ; Decrease, Apoptosis of ciliated epithelial cells ; Increase, Mucin production ; Chronic, Mucus hypersecretion ; Decrease, Lung function
  • 11/29/2016 11:41:17 PM
  • 6/19/2017 3:11:02 PM
  • AOP under development
  • 1.51
Source: https://aopwiki.org/
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
Increased, induction of UDPGT's in liver ; Increased, T4/T3 catabolism ; Decreased, serum T4/T3 ; Increased, Thyroid-stimulating hormone (TSH) ; Increased, Hypertrophy and proliferation (follicular cell) ; Increased, Hyperplasia (follicular cells) ; Increased Apoptosis, Adenomas/carcinomas (follicular cell)
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:14:41 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Epigenetic modification of PPARG leading to adipogenesis
peroxisome proliferator activated receptor promoter demethylation ; Activation of specific nuclear receptors, PPAR-gamma activation ; chronic high fat diet ; activation of CCAAT/enhancer-binding protein alpha ; increased adipogenesis ; decreased dopamine ; decreased reward ; decreased DNA methylation of tyrosine hydroxylase ; decreased methylation of dopamine transporter promoter ; obesity
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:15:37 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
Increase, Inflammation ; Increase, Papillomas/carcinomas (squamous cells) ; Increase, Cytotoxicity (epithelial cells) ; Increase, Regenerative cell proliferation (forestomach epithelial cells) ; Increase, Hyperplasia (forestomach epithelial cells)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:16:48 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER agonism leading to reduced survival due to renal failure
Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increased, Vitellogenin synthesis ; Increased, renal vitellogenin deposition ; Increased, glomerular rupture and renal hemorrhaging ; Increased, nephropathy
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:18:29 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
Agonism, Estrogen receptor ; skewed, sex ratio
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:19:20 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER mediated breast cancer AOP
  • 11/29/2016 11:41:17 PM
  • 3/8/2017 3:21:27 PM
Source: https://aopwiki.org/
Estrogen Binding Mediated Population Reduction
Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Estrogen Receptor Activation and Female Precocious Puberty
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:20:50 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Estrogen receptor activation leading to breast cancer
N/A, Mitochondrial dysfunction 1 ; Increased, Oxidative Stress ; Activation, Estrogen receptor ; Increase, Cell Proliferation (Epithelial Cells) ; Decreased, Apoptosis (Epithelial Cells) ; Increased, ER binding to DNA (classical pathway) ; Increased, ER binding to T.F. to DNA (non-classical pathway) ; Increased, Proliferation (Endothelial cells) ; Increased, Migration (Endothelial Cells) ; Increased, Non-genomic signaling ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; modulation, Extracellular Matrix Composition ; Increased, Invasion ; Activation, Fibroblasts ; Activation, Macrophages ; Increased, Angiogenesis ; Altered, Gene Expression ; Altered, Protein Production ; Increased, Motility ; Increased, Second Messenger Production ; N/A, Breast Cancer
  • 11/29/2016 11:41:17 PM
  • 3/8/2017 3:21:28 PM
Source: https://aopwiki.org/
Estrogen receptor agonism leading to reproductive dysfunction
Reduction, Cumulative fecundity and spawning ; Decrease, Population trajectory ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increase, Vitellogenin synthesis in liver ; Increase, Renal pathology due to VTG deposition ; Altered, Reproductive behaviour ; Altered, Larval development ; Impaired development of, Reproductive organs
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:21:34 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Estrogen receptor antagonism leading to reproductive dysfunction
Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Antagonism, Estrogen receptor
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:41:56 PM
  • EAGMST under review
  • 1.12
Source: https://aopwiki.org/
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:23:27 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Example6 Neurotoxicity
Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Excessive reactive oxygen species production leading to reproductive dysfunction
Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Peptide Oxidation ; Decrease, Ovulation ; Decrease, Fertility ; Increase, DNA damage ; Excessive reactive oxygen species formation ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia
  • 4/15/2017 8:00:03 PM
  • 6/30/2017 3:11:01 PM
Source: https://aopwiki.org/
Excessive reactive oxygen species production leading to reproductive failure
Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Decrease, Fertility ; Decrease, Oogenesis ; Increase, Lipid peroxidation ; Increase, Uncoupling of oxidative phosphorylation
  • 6/29/2017 12:00:09 PM
  • 6/30/2017 3:11:01 PM
Source: https://aopwiki.org/
Gastric ulcer formation
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Increase, bicarbonate ; Increase, mucous ; Increase, mucosal blood flow ; Increase, platelet aggregation ; Increase, angiogenesis ; Decrease, leukocyte adherence ; Increase, leukocyte adherence ; Activate, leukocyte ; Activate, mucosal defense ; Increase, surfactant ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Inhibit, gastric ulcer formation ; Activated, gastric ulcer formation
  • 4/17/2017 2:11:46 PM
  • 4/18/2017 3:13:59 PM
Source: https://aopwiki.org/
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
impaired, Fertility ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Glucocorticoid Receptor Agonist, Activation ; Repressed expression of steroidogenic enzymes ; Increased apoptosis, decreased number of adult Leydig Cells ; Decreased Sperm Number, Reduced Fertility ; Accelerated Epididymal Sperm Transit, Reduced Fertility ; Abnormal Sperm Maturation, Reduced Fertility ; Decreased sperm quantity or quality in the adult, Decreased fertility
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:25:16 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
Activation, Glucocorticoid Receptor ; Inhibition, Nuclear factor kappa B (NF-kB) ; Suppression, Inflammatory cytokines ; Decreased, Lymphocytes ; Induction, IKB inhibitory protein ; Suppression, Immune system ; Increased, Disease susceptibility
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:25:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glutamate-gated chloride channel activation leading to acute mortality
Increased, Mortality ; Activation, Glutamate-gated chloride channel ; Increased, Chloride conductance ; hyperpolarisation, neuron ; N/A, Ataxia, paralysis, or hyperactivity ; Decreased, population 1
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 8:27:08 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
Increased, Mortality ; Increased, Chloride conductance ; Increased, Inhibitory postsynaptic potential ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Induction, pharyngeal muscle paralysis
  • 11/29/2016 11:41:17 PM
  • 3/8/2017 3:20:51 PM
Source: https://aopwiki.org/
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, prolactin exposure ; Hyperplasia, Mammary gland ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary)
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:28:07 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, lactotroph hyperplasia and hypertrophy ; Increased, adenomas (pituitary)
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 8:28:24 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Handbook development AOP
  • 2/16/2017 4:26:17 PM
  • 3/8/2017 3:21:39 PM
Source: https://aopwiki.org/
Helicobacter pylori to gastric ulcer
Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Activated, gastric ulcer formation ; Reduced, mucosal defense ; Helicobacter pylori infection
  • 6/2/2017 3:06:41 PM
  • 6/3/2017 3:12:08 PM
Source: https://aopwiki.org/
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Activation, Hepatic nuclear receptor(s) ; Increased, Hepatic thyroid hormone uptake/transport
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 9:34:22 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Histamine (H2) receptor antagonism leading to reduced survival
Impairment, Learning and memory ; Increased, predation ; Antagonism, Histamine Receptor (H2) ; Decrease, histaminergic neuron excitation ; N/A, sedation ; Decreased, locomotion ; impaired, Learning and memory ; Decreased, survival
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:35:09 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Histone deacetylase inhibition leading to testicular toxicity
  • 3/10/2017 11:45:47 AM
  • 6/10/2017 9:36:32 PM
  • AOP under development
  • 1.52
Source: https://aopwiki.org/
HMG-CoA reductase inhibition leading to decreased fertility
Inhibition, HMG-CoA reductase ; Decreased, mevalonate ; Decreased, cholesterol ; Decreased, Testosterone ; malformed, Male reproductive tract ; Decrease, Fertility
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:37:41 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
HNF4alpha suppression leading to hepatic steatosis
Suppression, HNF4alpha
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:39:04 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme ; Increased, Plasma tyrosine ; Increase, Cytotoxicity (corneal cells) ; Increase, Inflammation (corneal cells) ; Increase, Regenerative cell proliferation (corneal cells) ; Increase, Papillomas/carcinomas (squamous cells)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:40:00 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
Increase, Dopaminergic activity ; Decreased, Prolactin ; Increased, Estrogen receptor (ER) activity ; Decreased, Progesterone from corpus luteum ; Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Increase, Endometrial adenocarcinomas
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:42:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increase, Energetic demands and therefore metabolic stress ; Increased, Appetite and hunger
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:47:03 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
Increase, Hyperplasia (Leydig cells) ; Increase, Leydig cell tumors ; Inhibition, 5α-reductase activity ; Increased, Leutinizing hormone (LH) ; Decrease, Bioactivation of testosterone
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 9:48:18 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of ATP synthase
Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
Binding, Immunophilins ; Inhibition, Calcineurin Activity ; Interference, nuclear localization of NFAT ; Reduction, NFAT complex formation ; Suppression, IL-2 and IL-4 production ; Suppression, Suppression of production of cytotoxic T-cells ; Suppression, Suppression of T-cell dependent antibody production ; Impairment, T-cell dependent antibody response ; Relief, Relief of atopic dermatitis ; Increase, Increased susceptibility to infection
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 9:49:30 PM
  • EAGMST under review
  • 1.38
Source: https://aopwiki.org/
Inhibition of complexes I-IV
Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Locomotor activity, decreased
  • 5/2/2017 2:41:02 PM
  • 5/9/2017 3:11:01 PM
Source: https://aopwiki.org/
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Sexual behavior, decreased
  • 5/3/2017 3:40:04 PM
  • 5/9/2017 3:11:01 PM
Source: https://aopwiki.org/
Inhibition of histone deacetylases class I
Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
Production, Critical Metabolites (CGA 330050 and CGA 265307) ; Induction, Liver “Dysfunctional” Changes by CGA 330050 ; Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 ; Induction, Sustained Hepatotoxicity ; Induction, Sustained Cell Proliferation ; Formation, Liver tumor
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:19:01 PM
Source: https://aopwiki.org/
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
Decreased, Uptake of inorganic iodide ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 10:43:49 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
Decreased, survival ; Reduced, Swimming performance ; Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts ; Inhibition of lysyl oxidase ; Reduction of collagen crosslinking ; Weak collagen matrix ; Notochord distortion or malformations ; Growth, reduction
  • 8/3/2017 1:52:03 PM
  • 8/4/2017 3:12:20 PM
Source: https://aopwiki.org/
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Reduced levels of BDNF ; Impairment, Learning and memory ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decrease of GABAergic interneurons
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 10:45:45 PM
  • EAGMST under review
  • 1.28
Source: https://aopwiki.org/
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Peptide Oxidation ; Increase, Adenomas/carcinomas (hepatocellular) ; Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme ; Increase, Cytotoxicity ; Increased, Induction of pyruvate dehydrogenase (PDH) ; Increase, Oxidative metabolism
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 10:47:04 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of the enzyme 5-alpha reductase type 2
Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; impaired, Proteostasis ; N/A, Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits
  • 11/29/2016 11:41:15 PM
  • 9/8/2017 3:11:02 PM
  • EAGMST under review
  • 1.33
Source: https://aopwiki.org/
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
Thyroperoxidase, Inhibition ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 10:48:46 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 10:55:26 PM
  • EAGMST under review
  • 1.10
Source: https://aopwiki.org/
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Cognitive Function, Decreased ; Binding, Transthyretin in serum ; Displacement, Serum thyroxine (T4) from transthyretin ; Increased, Free serum thyroxine (T4) ; Increased, Uptake of thyroxine into tissue ; Increased, Clearance of thyroxine from tissues
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 10:56:58 PM
  • AOP under development
  • 1.41
Source: https://aopwiki.org/
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
Increase, Cytotoxicity ; Decrease, Intracellular pH ; Increase, Tissue Degeneration, Necrosis & Atrophy ; Increase, Cell Proliferation ; Increase, Respiratory or Squamous Metaplasia ; Increase, Mutations in Critical Genes ; Increase, Site of Contact Nasal Tumors
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:44:56 PM
  • EAGMST under review
  • 2.7
Source: https://aopwiki.org/
In-utero DNA topoisomerase II poisons leading to infant leukaemia
In-utero DNA topoisomerase II “poisons- ; In utero MLL chromosomal translocation ; Infant leukaemia ; DNA double-strand break
  • 12/16/2016 9:38:16 AM
  • 6/10/2017 9:41:22 PM
  • EAGMST under review
  • 1.53
Source: https://aopwiki.org/
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Iodotyrosine deiodinase (IYD)
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:03:03 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
Increased, Mortality ; Increased, Chloride conductance ; Activation, ionotropic GABA Receptor chloride channel ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding
  • 11/29/2016 11:41:17 PM
  • 3/8/2017 3:20:50 PM
Source: https://aopwiki.org/
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
Reproductive failure ; Activation, JAK/STAT pathway ; Activation, TGF-beta pathway
  • 2/15/2017 8:44:35 AM
  • 3/8/2017 3:21:36 PM
Source: https://aopwiki.org/
Juvenile hormone receptor agonism leading to male offspring induction associated population decline
Decline, Population ; Activation, Juvenile hormone receptor ; Induction, Doublesex1 gene ; Induction, Male reproductive tract ; Increased, Male offspring ; Alteration, Food-web structures
  • 11/29/2016 11:41:17 PM
  • 3/8/2017 3:21:29 PM
Source: https://aopwiki.org/
Kidney dysfunction by decreased thyroid hormone
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Glomerular filtration ; Decreased, Renal plasma flow ; Decreased, Sodium reabsorption ; Increased, Serum creatinine ; Occurrence, Cystic dilatation (renal tubule) ; Occurrence, Cytoplasmic vacuolization (podocyte) ; Occurrence, Cytoplasmic vacuolization (Renal tubule) ; Decreased, Renal ability to dilute urine ; Occurrence, Kidney toxicity
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:04:21 PM
  • AOP under development
  • 1.40
Source: https://aopwiki.org/
Kidney toxicity induced by activation of 5HT2C
Activation, 5HT2c ; N/A, Unknown ; Increased, Kidney Failure
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:19:02 PM
Source: https://aopwiki.org/
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
Increase, Reactive oxygen species production ; Accumulation, Collagen ; Increased, secretion of local growth factors ; Expression of Collagen ; Collagen Deposition ; Induction, Cell damage sensing ; Incudtion, Sustained inflammatory cytokine release ; Increase, Differentiation of fibroblasts ; Induction, Epithelial Mesenchymal Transition ; Pulmonary fibrosis ; Activation, Latent Transforming Growth Factor Beta 1 ; Activation, Transforming Growth Factor beta pathway
  • 7/26/2017 10:54:43 PM
  • 8/16/2017 3:11:07 PM
Source: https://aopwiki.org/
LXR activation leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Increase, FA Influx ; Activation, ChREBP ; Activation, SREBP-1c ; Activation, FAS ; Activation, SCD-1 ; Synthesis, De Novo FA ; Accumulation, Triglyceride ; Damaging, Mitochondria ; N/A, Liver Steatosis
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:19:04 PM
Source: https://aopwiki.org/
Lysosomal damage leading to liver inflammation
N/A, Mitochondrial dysfunction 1 ; N/A, Cell injury/death ; Release, Cytokine ; Peptide Oxidation ; Disruption, Lysosome ; Infiltration, Inflammatory cells ; Inflammation, Liver
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:05:26 PM
  • AOP under development
  • 1.47
Source: https://aopwiki.org/
Mental stress to agitation
Activation, Glucocorticoid Receptor ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, glucocorticoid receptor activity
  • 5/30/2017 7:12:23 PM
  • 6/2/2017 3:11:05 PM
Source: https://aopwiki.org/
Mental stress to depression
Activation, Glucocorticoid Receptor ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, depression ; Decreased, extracellular serotonin ; Increased, glucocorticoid receptor activity
  • 5/30/2017 5:56:15 PM
  • 6/2/2017 3:11:05 PM
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased corticosterone ; Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:07:01 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:08:00 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol ; Decreased Cholesterol, Decreased Uptake of Lipoproteins ; Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane ; Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells ; Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:08:20 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased estradiol ; Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists ; decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:08:41 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
Decreased sperm quantity or quality in the adult, Decreased fertility ; Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid ; Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells ; Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells ; Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:09:32 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis ; Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:09:52 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell ; Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells ; Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells ; Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton ; Decreased sperm quantity or quality in the adult, Decreased fertility
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:10:29 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Molecular events lead to epilepsy
Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Inactive, membrane depolarization ; Increased, RDX dose ; Repress, GABA-A receptor ; Activate, GABA-A receptor ; Activate, presynaptic neuron 2 ; Increase, GABA ; Increase, seizure ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
  • 4/14/2017 6:58:30 PM
  • 4/15/2017 3:13:54 PM
Source: https://aopwiki.org/
Molecular events lead to nonalcoholic hepatic steatosis (NASH)
Activation, PPARα ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Activation, FAS ; Activation, SCD-1 ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Inhibition, PPAR alpha ; Activation, NRF2 ; Activation, SHP ; Increase, insulin ; Activation, insulin receptor ; Activation, mTORC2 ; Activation, AKT ; Activation, mTORC1 ; Activation, SREBP-1 ; Activation, L-FABP ; Increase, cytosolic fatty acid ; Increased, lipogenesis ; Activation, FXR ; Activation, HSD17B4 ; Inhibition, LXR ; Inhibition, LRH-1 ; Activation, aPKC ; Activation, PI3K ; Inhibition, Steatosis ; Induction, fatty acid beta-oxidation ; Decrease, cytosolic fatty acid ; Activation, LRH-1
  • 4/12/2017 5:28:27 PM
  • 4/13/2017 3:14:27 PM
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
Mu Opioid Receptor Agonism ; Release of G Proteins ; Analgesia ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release
  • 6/23/2017 10:33:09 AM
  • 6/23/2017 3:14:19 PM
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
hyperpolarisation, neuron ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Analgesia
  • 6/8/2017 3:54:18 PM
  • 6/9/2017 3:14:03 PM
Source: https://aopwiki.org/
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans : Case study on silver nanoparticle
Damaging, Mitochondria ; Apoptosis ; Activation, NADPH Oxidase ; ROS formation ; Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK ; Activation, HIF-1 ; Increased, DNA Damage-Repair ; Reproductive failure
  • 2/15/2017 8:09:24 AM
  • 3/8/2017 3:21:35 PM
Source: https://aopwiki.org/
Narcosis leading to respiratory failure
Accumulation, Biological membranes ; Disruption, Membrane integrity
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:11:44 PM
  • AOP under development
  • 1.2
Source: https://aopwiki.org/
Network of SSRIs (selective serotonin reuptake inhibitors)
Activation, Glucocorticoid Receptor ; Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Decreased, extracellular sodium (Na+) ; Decreased, extracellular chloride (Cl-) ; Increased, extracellular serotonin ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increased, seizure ; Increased, agitation ; Increased, depression ; Increase, hypertension ; Decreased, extracellular serotonin
  • 4/13/2017 6:11:48 PM
  • 4/14/2017 3:13:56 PM
Source: https://aopwiki.org/
NFE2/Nrf2 repression to steatosis
NFE2/Nrf2 repression ; Reduced, FXR activity ; Reduced, SHP activity ; Activated, LXR ; Reduced, PPARalpha ; Reduced, HSD17B4 activity ; Reduced, fatty acid beta oxidation ; Increased, steatosis
  • 6/2/2017 8:26:43 PM
  • 6/3/2017 3:12:09 PM
Source: https://aopwiki.org/
NFE2L2/FXR activation leading to hepatic steatosis
Activation, PPARα ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, De Novo FA synthesis ; Increased, Liver Steatosis ; Activation, NRF2 ; Activation, NR1H4 ; Activation, SHP ; Decreased, DHB4/HSD17B4 ; Activation, LXR alpha ; Inhibition, SREBP1c ; Activation, MTTP ; Increased, ApoB100 ; Increased, Triglyceride ; FA synthesis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:12:54 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:14:12 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste
  • 11/29/2016 11:41:16 PM
  • 6/20/2017 3:11:02 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 6/20/2017 3:11:02 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:16:26 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:16:47 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Accumulation, Damaged mitochondrial DNA ; Accelerated, Aging ; Overwhelmed, Mitochondrial DNA repair mechanisms ; Decrease, Number of worker bees
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:17:15 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; impaired, Hive thermoregulation
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:17:54 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:20:15 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 6/20/2017 3:11:02 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nosema infection causes abnormal role change that leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Abnormal, Role change within caste
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:21:06 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nosema infection increases energetic demands leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Increased, Energetic demands and therefore metabolic stress
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:21:35 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
Activation, PXR/SXR ; Up Regulation, CD36 ; Accumulation, Fatty acid ; Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Increased, Liver Steatosis ; Inhibition, FoxA2 ; Down Regulation, CPT1A ; Down Regulation, HMGCS2 ; Increased, Hepatic Triglycerides ; Accumulation, Hepatic FA ; Decreased, Ketogenesis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:24:14 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
NR1I3 (CAR) suppression leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Activation, ChREBP ; Accumulation, Fatty acid ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Suppression, Constitutive androstane receptor, NR1l3 ; Inhibition, PPAR alpha ; Activation, SREBF1 ; Increased, De Novo FA synthesis ; Increased, Fatty acid uptake ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Up Regulation, FAS ; Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) ; Increased, Liver Steatosis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:25:12 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
NSAID induced PTGS1 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS1 function ; Reduced, platelet aggregation ; Decreased, mucosal blood flow ; Reduced, mucosal defense ; Decreased, mucous ; Decreased, bicarbonate
  • 6/2/2017 2:20:27 PM
  • 6/3/2017 3:12:07 PM
Source: https://aopwiki.org/
NSAID induced PTGS2 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS2 function ; Decreased, angiogenesis ; Increased, leukocyte adherence ; Increased, leukocyte activation
  • 6/2/2017 2:50:59 PM
  • 6/3/2017 3:12:07 PM
Source: https://aopwiki.org/
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
Increased, Mortality ; Decline, Population ; Inhibition, organic anion transporter 1 (OAT1) ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:26:17 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Oxidation of hemoglobin Mediated Population Reduction
Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Oxidation of iron in hemoglobin leading to hematotoxicity
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) ; Altered regulation, Alpha hemoglobin ; Propagation, Oxidative stress ; Damaging, Red blood cells; hemolysis ; Formation, Formation of hemoglobin adducts ; Down Regulation, Gulcose-6-phosphate dehydrogenase ; Increase, RBC congestion in liver ; Increase, Liver and splenic hemosiderosis ; N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number ; N/A, Cyanosis occurs
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:27:16 PM
  • AOP under development
  • 1.16
Source: https://aopwiki.org/
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling
  • 7/14/2017 5:34:19 PM
  • 7/15/2017 3:12:17 PM
Source: https://aopwiki.org/
Pathway newrok: NMDA, nACh, GABA A, receptor binding leading to population reduction
Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Pendrin inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Pendrin
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:29:17 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Peptide Oxidation Leading to Hypertension
Peptide Oxidation ; Oxidation, Glutathione ; S-Glutathionylation, eNOS ; Decrease, GTPCH-1 ; Decrease, Tetrahydrobiopterin ; Uncoupling, eNOS ; Depletion, Nitric Oxide ; impaired, Vasodilation ; Increase, Vascular Resistance ; Decrease, Akt/eNOS activity ; Hypertension
  • 11/29/2016 11:41:17 PM
  • 8/15/2017 3:11:07 PM
  • AOP under development
  • 1.50
Source: https://aopwiki.org/
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol
Activation, PXR/SXR
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:30:53 PM
  • AOP under development
  • 2.5
Source: https://aopwiki.org/
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
Decreased, PPAR-alpha activation ; Decreased, PPAR-beta activation ; Decreased, PPAR-gamma activation ; Accumulation, Fatty acid ; Decreased, HSD17B10 expression ; Decreased, Mitochondrial fatty acid beta-oxidation ; Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity ; Undefined, Liver Steatosis ; Increased, Liver Steatosis
  • 11/29/2016 11:41:16 PM
  • 3/8/2017 3:19:06 PM
Source: https://aopwiki.org/
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
Inactivation of PPARγ ; Activation of TGF-β signaling ; Differentiation of Myofibroblast ; Production of α-smooth muscle actin ; Expression of Collagen ; Collagen Deposition ; Lung fibrosis
  • 2/15/2017 7:34:56 AM
  • 6/10/2017 11:31:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity
  • 2/15/2017 8:56:47 AM
  • 3/8/2017 3:21:37 PM
Source: https://aopwiki.org/
Phospholipase A inhibitors lead to hepatotoxicity
Inhibition, Phospholipase A ; Damage, Lipid bilayer ; Disturbance, Lysosomal function ; Injury, Mitochondria ; Occurrence, Cytoplasmic vacuolization (hepatocyte) ; Occurrence, Ballooning degeneration (hepatocyte) ; Occurrence, Cytoplasmic vacuolization (kupffer cell) ; Induction, Microvesicular fat ; Formation, Mallory body ; Occurrence, Cytoplasmic vacuolization (Bile duct cell) ; Formation, Liver fibrosis
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:52:25 PM
  • AOP under development
  • 1.39
Source: https://aopwiki.org/
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
Increased, PPAR-alpha activation ; Decreased, bile flow ; Increased, cholestasis ; Alteration, lipid metabolism ; prolonged, elevation of serun CCK ; Increased, Cellular proliferation / hyperplasia of acinar cells ; Increased, Pancreatic acinar tumors
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:53:54 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
PPARalpha-dependent liver cancer
Activation, PPARα ; modulation, Genes/proteins that regulate hepatocyte fate ; Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci ; Increase, Adenomas/carcinomas (hepatocellular)
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:55:08 PM
  • AOP under development
  • 1.17
Source: https://aopwiki.org/
PPARgamma activation leading to sarcomas in rats, mice, and hamsters
Activation of specific nuclear receptors, PPAR-gamma activation ; Increased, adipogenesis ; Increased, secretion of local growth factors ; Increased, proliferation of mesenchymal cells ; Increased, IGF-1 (mouse) ; Increased, Firbrosarcoma ; Increased, liposarcoma ; Increased, hemagiosarcoma
  • 11/29/2016 11:41:17 PM
  • 6/10/2017 11:56:04 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
PPARα activation in utero leading to impaired fertility in males
impaired, Fertility ; Activation, PPARα ; Decrease, Steroidogenic acute regulatory protein (STAR) ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Decrease, Translocator protein (TSPO) ; Malformation, Male reproductive tract
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:45:59 PM
  • EAGMST under review
  • 1.21
Source: https://aopwiki.org/
PPARα activation leading to impaired fertility in adult male rodents
impaired, Fertility ; Activation, PPARα ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Increase, Luteinizing hormone (LH) ; Hyperplasia, Leydig cell ; Increase proliferation, Leydig cell
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:57:46 PM
  • AOP under development
  • 1.21
Source: https://aopwiki.org/
presynaptic neuron 1 activation to epilepsy
Increased, intracellular sodium (Na+) ; Increased, seizure ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
  • 6/2/2017 3:27:37 PM
  • 6/3/2017 3:12:08 PM
Source: https://aopwiki.org/
presynaptic neuron 2 repression to epilepsy
Increased, seizure ; Activated, membrane depolarization ; Increased, RDX dose ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Reduced, presynaptic neuron 2 activity ; Decreased, GABA ; Reduced, GABA-A receptor activation ; Decreased, intracellular chloride
  • 6/2/2017 4:07:00 PM
  • 6/3/2017 3:12:08 PM
Source: https://aopwiki.org/
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Prolyl hydroxylases ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA
  • 11/29/2016 11:41:16 PM
  • 6/10/2017 11:58:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Protein Alkylation leading to Liver Fibrosis
N/A, Cell injury/death ; Alkylation, Protein ; Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) ; Up Regulation, TGFbeta1 expression ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 2:43:10 PM
  • OECD endorsed (WNT and WPHA)
  • 1.14
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Queen egg-laying decrease leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:00:13 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Retinoic acid signalling leading to developmental toxicity
Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid
  • 4/11/2010 10:00:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression
Sensing of the stressor by pulmonary cells ; Increased production of pulmonary, pro-inflammatory cytokines ; Increased production of pulmonary SAA ; Formation of HDL-SAA ; Increased systemic total cholesterol pool ; Foam cell formation ; Plaque progression in arteries
  • 6/29/2017 5:37:35 AM
  • 6/29/2017 3:13:14 PM
Source: https://aopwiki.org/
Secretion of inflammatory cytokines leading to lung fibrosis
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:01:37 AM
  • AOP under development
  • 1.32
Source: https://aopwiki.org/
Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins
N/A, Covalent binding to protein, possibly lysine residue ; Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways ; Increase, Allergic Respiratory Hypersensitivity Response
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:03:40 AM
  • AOP under development
  • 1.20
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
Release of G Proteins ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
  • 6/23/2017 11:21:13 AM
  • 6/23/2017 3:14:20 PM
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
hyperpolarisation, neuron ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
  • 6/23/2017 11:02:54 AM
  • 6/23/2017 3:14:20 PM
Source: https://aopwiki.org/
Serotonin transporter activation to agitation
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
  • 5/31/2017 12:08:34 AM
  • 6/2/2017 3:11:06 PM
Source: https://aopwiki.org/
Serotonin transporter activation to depression
Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, depression ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
  • 5/30/2017 7:58:08 PM
  • 6/2/2017 3:11:06 PM
Source: https://aopwiki.org/
Serotonin transporter activation to seizure
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Increased, seizure ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Decreased, 5-HT3
  • 5/30/2017 7:45:53 PM
  • 6/2/2017 3:11:06 PM
Source: https://aopwiki.org/
Sodium channel (Nav1.1) inhibition leading to population decline
Inhibition, sodium channel ; Decreased, sodium conductance 2 ; Decreased, GABA release
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:05:32 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium channel inhibition leading to congenital malformations
Increased, Atrioventricular block and bradycardia ; Increased, Respiratory distress/arrest ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; N/A, hypoxia ; Increased, amputations
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:05:59 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
sodium channel inhibition leading to increased predation
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Increased, predation
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:06:26 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium channel inhibition leading to reduced survival
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:06:51 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:07:12 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:07:36 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
SSRI (Selective serotonin reuptake inhibitor) to hypertension
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increase, hypertension ; Decreased, extracellular serotonin
  • 5/31/2017 12:30:22 AM
  • 5/31/2017 3:12:26 PM
Source: https://aopwiki.org/
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
Suppression, Immune system ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increased, Viral susceptibility
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:08:39 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Suppression of immune system contributes to impaired development and leads to colony loss/failure
Suppression, Immune system ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; impaired, Development
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:09:01 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sustained AhR Activation leading to Rodent Liver Tumours
Activation, Long term AHR receptor driven direct and indirect gene expression changes ; N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects ; Changes/Inhibition, Cellular Homeostasis and Apoptosis ; Alterations, Cellular proliferation / hyperplasia ; Formation, Hepatocellular and Bile duct tumors
  • 11/29/2016 11:41:16 PM
  • 3/10/2017 3:46:51 PM
  • EAGMST under review
  • 1.7
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:11:42 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation
Thyroxine (T4) in serum, Decreased ; Decrease, Population trajectory ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:12:06 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
Decreased, Triiodothyronine (T3) in serum ; Inhibition, Deiodinase 1 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:13:06 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:13:37 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 3 ; Increased, Triiodothyronine (T3) in tissues
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:14:00 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition
Decrease, Mitochondrial ATP production ; Increase, Uncoupling of photophosphorylation ; Decrease, Chloroplast ATP production ; Decrease, Chlorophyll synthesis ; Decrease, Light harvest capacity ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Leaf cell mitosis ; Decrease, Leaf development ; Increase, Growth inhibition
  • 10/10/2017 11:43:35 AM
  • 10/10/2017 3:15:03 PM
Source: https://aopwiki.org/
unknown MIE leading to renal failure and mortality
Increased, Mortality ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Unknown, MIE ; Increased, Reactive oxygen species
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:15:02 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; modulation, Unknown ; Increased, HIF-1 alpha transcription
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:15:20 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Activation, Pregnane-X receptor, NR1l2 ; Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Loss, Cochlear function
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:16:20 AM
  • AOP under development
  • 1.9
Source: https://aopwiki.org/
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
Increase, Urinary bladder calculi ; Increase, Cytotoxicity (urothelial cells) ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Increase, Adenomas/carcinomas (urothelial)
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:17:15 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:18:27 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Varroa mite infestation increases virus levels leading to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Increased, Deformed Wing Virus levels
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:18:44 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Vinclozoline case study
Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
TRPA1 activation, TRPA1 Receptor ; TRPV1 activation, TRPV1 ; Activation of oxidative stress pathway ; Opening of calcium channel, Calcium influx ; Excitation, Neuron nerve ending excitation ; SP (Substance P) release, Local increase of SP ; Non-neuronal production of TNF, Epithelial irritation ; Immune system inflammation ; Production of nerve growth factor , Epithelial irritation ; Non-neuronal production of IL-8/CXCL1, Epithelial irritation ; Generation of novel epitopes , Antigen presentation ; Trigeminal and/or vagal nerve excitation ; Chronic Cough, Respiratory irritability ; Sensitization, Immune system ; Increase, hypertension ; Increased CGRP, neuronal release of CGRP ; Increased neurokinin A (NKA) by neuronal cells ; Irritation of nasal mucosa inducing sneeze reflex
  • 11/29/2016 11:41:17 PM
  • 6/23/2017 3:11:02 PM
Source: https://aopwiki.org/
Weak acid respiratory uncoupling leading to death
Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction
  • 10/15/2008 11:30:00 AM
  • 3/8/2017 3:23:37 PM
Source: http://www.effectopedia.org/
Weather event contributes abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:19:30 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Weather event contributes to colony loss/failure
Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 6/11/2017 12:19:51 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
Inhibition, Inhibition of Dopamine-beta-hydroxylase ; Decreased, Synthesis of NE ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity
  • 11/29/2016 11:41:16 PM
  • 6/11/2017 12:20:52 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
impaired, Proteostasis
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Source: https://aopwiki.org/
Parkinsonian motor deficits
Source: https://aopwiki.org/
Activation, Ecdysone receptor
Source: https://aopwiki.org/
Induction, Nuclear receptor E75b gene
Source: https://aopwiki.org/
Suppression, Fushi tarazu factor-1 gene
Source: https://aopwiki.org/
Reduction, Release of circulating ecdysis triggering hormone
Source: https://aopwiki.org/
Reduction, Release of circulating crustacean cardioactive peptide
Source: https://aopwiki.org/
Reduction, Ecdysis motoneuron bursts
Source: https://aopwiki.org/
Reduction, Excitatory postsynaptic potential
Source: https://aopwiki.org/
Reduction, Abdominal muscle contraction
Source: https://aopwiki.org/
Induction, Incomplete ecdysis
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Increased, Mortality
Source: https://aopwiki.org/
Binding of antagonist, PPAR alpha
Source: https://aopwiki.org/
Decreased, PPARalpha transactivation of gene expression
Source: https://aopwiki.org/
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
Decreased, Ketogenesis (production of ketone bodies)
Source: https://aopwiki.org/
Not Increased, Circulating Ketone Bodies
Source: https://aopwiki.org/
Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids
Source: https://aopwiki.org/
Increased, Catabolism of Muscle Protein
Source: https://aopwiki.org/
stabilization, PPAR alpha co-repressor
Source: https://aopwiki.org/
Decreased, Body Weight
Source: https://aopwiki.org/
reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
irregularities, ovarian cycle
Source: https://aopwiki.org/
Activation, Pregnane-X receptor, NR1l2
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Loss, Cochlear function
Source: https://aopwiki.org/
Binding at picrotoxin site, iGABAR chloride channel
Source: https://aopwiki.org/
Reduction, Ionotropic GABA receptor chloride channel conductance
Source: https://aopwiki.org/
Occurrence, A paroxysmal depolarizing shift
Source: https://aopwiki.org/
Reduction, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Generation, Amplified excitatory postsynaptic potential (EPSP)
Source: https://aopwiki.org/
Occurrence, Epileptic seizure
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Aberrant, Dendritic morphology
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Reduced, Presynaptic release of glutamate
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Suppression, Inflammatory cytokines
Source: https://aopwiki.org/
Decreased, Lymphocytes
Source: https://aopwiki.org/
Induction, IKB inhibitory protein
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Increased, Disease susceptibility
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
N/A, Insufficient or incorrect DNA repair
Source: https://aopwiki.org/
N/A, Insufficient or incorrect DNA repair
Source: https://aopwiki.org/
Increase, Heritable mutations in offspring
Source: https://aopwiki.org/
Inhibition, Acetylcholinesterase (AchE)
Source: https://aopwiki.org/
Accumulation, Acetylcholine in synapses
Source: https://aopwiki.org/
Increased, Atrioventricular block and bradycardia
Source: https://aopwiki.org/
Increased, Atrioventricular block and bradycardia
Source: https://aopwiki.org/
Increased, Respiratory distress/arrest
Source: https://aopwiki.org/
Increased, Respiratory distress/arrest
Source: https://aopwiki.org/
Induction, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Binding, SH-/selen-proteins
Source: https://aopwiki.org/
N/A, Interferences with SH-/selen-proteins
Source: https://aopwiki.org/
Depletion, GSH
Source: https://aopwiki.org/
N/A, Oxidative stress
Source: https://aopwiki.org/
N/A, Neuronal dysfunction
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Decrease, Steroidogenic acute regulatory protein (STAR)
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Decrease, Translocator protein (TSPO)
Source: https://aopwiki.org/
Malformation, Male reproductive tract
Source: https://aopwiki.org/
N/A, Androgen receptor, Antagonism
Source: https://aopwiki.org/
Alteration, Wnt pathway
Source: https://aopwiki.org/
Feminisation or incomplete development, Primary and accessory male sex organs
Source: https://aopwiki.org/
Decreased, Transcription of genes by AR
Source: https://aopwiki.org/
N/A, Impairment of reproductive capacity
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
Increase, COX-2 expression
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Agonism, Androgen receptor
Source: https://aopwiki.org/
Reduction, Testosterone synthesis by ovarian theca cells
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Gonadotropins, circulating concentrations
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Inhibition, Aromatase
Source: https://aopwiki.org/
Inhibition, Ca++ ATPase
Source: https://aopwiki.org/
Increase, Ca++ (intracellular)
Source: https://aopwiki.org/
Disruption, Mitochondrial electron transport chain
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Decreased, Nitric Oxide
Source: https://aopwiki.org/
Decreased, Long-term potentiation (LTP)
Source: https://aopwiki.org/
Increased, Oxidative damage
Source: https://aopwiki.org/
Inhibition, Bile Salt Export Pump (ABCB11)
Source: https://aopwiki.org/
Activation of specific nuclear receptors, Transcriptional change
Source: https://aopwiki.org/
Bile accumulation, Pathological condition
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Production, Reactive oxygen species
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Pathways: Hypertension
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Cholestasis, Pathology
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Reduction, Prostaglandin E2 concentration
Source: https://aopwiki.org/
Reduction, Ca and HCO3 transport to shell gland
Source: https://aopwiki.org/
Reduction, Eggshell thickness
Source: https://aopwiki.org/
N/A, Gap
Source: https://aopwiki.org/
N/A, Reproductive failure
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Increase, Renal pathology due to VTG deposition
Source: https://aopwiki.org/
Altered, Reproductive behaviour
Source: https://aopwiki.org/
Altered, Larval development
Source: https://aopwiki.org/
Impaired development of, Reproductive organs
Source: https://aopwiki.org/
Antagonism, Estrogen receptor
Source: https://aopwiki.org/
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
Source: https://aopwiki.org/
Altered regulation, Alpha hemoglobin
Source: https://aopwiki.org/
Propagation, Oxidative stress
Source: https://aopwiki.org/
Damaging, Red blood cells; hemolysis
Source: https://aopwiki.org/
Formation, Formation of hemoglobin adducts
Source: https://aopwiki.org/
Down Regulation, Gulcose-6-phosphate dehydrogenase
Source: https://aopwiki.org/
Increase, RBC congestion in liver
Source: https://aopwiki.org/
Increase, Liver and splenic hemosiderosis
Source: https://aopwiki.org/
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
Source: https://aopwiki.org/
N/A, Cyanosis occurs
Source: https://aopwiki.org/
Production, Critical Metabolites (CGA 330050 and CGA 265307)
Source: https://aopwiki.org/
Induction, Liver “Dysfunctional” Changes by CGA 330050
Source: https://aopwiki.org/
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
Source: https://aopwiki.org/
Induction, Sustained Hepatotoxicity
Source: https://aopwiki.org/
Induction, Sustained Cell Proliferation
Source: https://aopwiki.org/
Formation, Liver tumor
Source: https://aopwiki.org/
Activation, 5HT2c
Source: https://aopwiki.org/
N/A, Unknown
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Increase, FA Influx
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, SREBP-1c
Source: https://aopwiki.org/
Activation, FAS
Source: https://aopwiki.org/
Activation, FAS
Source: https://aopwiki.org/
Activation, SCD-1
Source: https://aopwiki.org/
Activation, SCD-1
Source: https://aopwiki.org/
Synthesis, De Novo FA
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
N/A, Liver Steatosis
Source: https://aopwiki.org/
Accumulation, Biological membranes
Source: https://aopwiki.org/
Disruption, Membrane integrity
Source: https://aopwiki.org/
Decreased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, PPAR-beta activation
Source: https://aopwiki.org/
Decreased, PPAR-gamma activation
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Decreased, HSD17B10 expression
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Source: https://aopwiki.org/
Undefined, Liver Steatosis
Source: https://aopwiki.org/
modulation, Genes/proteins that regulate hepatocyte fate
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Alkylation, Protein
Source: https://aopwiki.org/
Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells)
Source: https://aopwiki.org/
Up Regulation, TGFbeta1 expression
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Covalent binding to protein, possibly lysine residue
Source: https://aopwiki.org/
Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
Source: https://aopwiki.org/
Increase, Allergic Respiratory Hypersensitivity Response
Source: https://aopwiki.org/
Covalent Binding, Protein
Source: https://aopwiki.org/
Activation, Keratinocytes
Source: https://aopwiki.org/
Activation, Dendritic Cells
Source: https://aopwiki.org/
Activation/Proliferation, T-cells
Source: https://aopwiki.org/
sensitisation, skin
Source: https://aopwiki.org/
Activation, Long term AHR receptor driven direct and indirect gene expression changes
Source: https://aopwiki.org/
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
Source: https://aopwiki.org/
Changes/Inhibition, Cellular Homeostasis and Apoptosis
Source: https://aopwiki.org/
Alterations, Cellular proliferation / hyperplasia
Source: https://aopwiki.org/
Formation, Hepatocellular and Bile duct tumors
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Inhibition, VegfR2
Source: https://aopwiki.org/
Reduction, Angiogenesis
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Insufficiency, Vascular
Source: https://aopwiki.org/
Increased, Developmental Defects
Source: https://aopwiki.org/
Formation, Pro-mutagenic DNA Adducts
Source: https://aopwiki.org/
Increased, Induced Mutations in Critical Genes
Source: https://aopwiki.org/
Metabolism of AFB1, Production of Reactive Electrophiles
Source: https://aopwiki.org/
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
Source: https://aopwiki.org/
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Source: https://aopwiki.org/
Tumorigenesis, Hepatocellular carcinoma
Source: https://aopwiki.org/
Binding of agonist, Ionotropic glutamate receptors
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Decreased, Neuronal network function in adult brain
Source: https://aopwiki.org/
Increase, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Hyperplasia, Leydig cell
Source: https://aopwiki.org/
Increase proliferation, Leydig cell
Source: https://aopwiki.org/
skewed, sex ratio
Source: https://aopwiki.org/
Increased, Vitellogenin synthesis
Source: https://aopwiki.org/
Increased, renal vitellogenin deposition
Source: https://aopwiki.org/
Increased, glomerular rupture and renal hemorrhaging
Source: https://aopwiki.org/
Increased, nephropathy
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of GABAergic interneurons
Source: https://aopwiki.org/
Suppression, VLDL secretion
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Source: https://aopwiki.org/
Increased, SCD-1
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Up Regulation, LDLR (low density lipoprotein receptor)
Source: https://aopwiki.org/
Increased, LDL uptake
Source: https://aopwiki.org/
Up Regulation, CYP1A1
Source: https://aopwiki.org/
Accumulation, Liver lipid
Source: https://aopwiki.org/
Suppression, Constitutive androstane receptor, NR1l3
Source: https://aopwiki.org/
Inhibition, PPAR alpha
Source: https://aopwiki.org/
Inhibition, PPAR alpha
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, Fatty acid uptake
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, FAS
Source: https://aopwiki.org/
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Suppression, HNF4alpha
Source: https://aopwiki.org/
Inhibition, FoxA2
Source: https://aopwiki.org/
Down Regulation, CPT1A
Source: https://aopwiki.org/
Down Regulation, HMGCS2
Source: https://aopwiki.org/
Increased, Hepatic Triglycerides
Source: https://aopwiki.org/
Accumulation, Hepatic FA
Source: https://aopwiki.org/
Decreased, Ketogenesis
Source: https://aopwiki.org/
Activation, NRF2
Source: https://aopwiki.org/
Activation, NRF2
Source: https://aopwiki.org/
Activation, NR1H4
Source: https://aopwiki.org/
Activation, SHP
Source: https://aopwiki.org/
Activation, SHP
Source: https://aopwiki.org/
Decreased, DHB4/HSD17B4
Source: https://aopwiki.org/
Activation, LXR alpha
Source: https://aopwiki.org/
Inhibition, SREBP1c
Source: https://aopwiki.org/
Activation, MTTP
Source: https://aopwiki.org/
Increased, ApoB100
Source: https://aopwiki.org/
Increased, Triglyceride
Source: https://aopwiki.org/
FA synthesis
Source: https://aopwiki.org/
systemic inflammation leading to hepatic steatosis
Source: https://aopwiki.org/
Activation, AKT2
Source: https://aopwiki.org/
Activtation, SREBP-1c
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Reduced, Prostaglandins, ovary
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Declining, Population trajectory
Source: https://aopwiki.org/
Declining, Population trajectory
Source: https://aopwiki.org/
Glucocorticoid Receptor Agonist, Activation
Source: https://aopwiki.org/
Repressed expression of steroidogenic enzymes
Source: https://aopwiki.org/
Increased apoptosis, decreased number of adult Leydig Cells
Source: https://aopwiki.org/
Decreased Sperm Number, Reduced Fertility
Source: https://aopwiki.org/
Accelerated Epididymal Sperm Transit, Reduced Fertility
Source: https://aopwiki.org/
Abnormal Sperm Maturation, Reduced Fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased corticosterone
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased estradiol
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
Source: https://aopwiki.org/
decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Uptake of Lipoproteins
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
Source: https://aopwiki.org/
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
Source: https://aopwiki.org/
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Inhibition, Inhibition of Dopamine-beta-hydroxylase
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Synthesis of NE
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Source: https://aopwiki.org/
Decreased, LH Surge
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, LH Surge
Source: https://aopwiki.org/
Delayed, Ovulation
Pathways: DBH inhibition
Source: https://aopwiki.org/
Delayed, Ovulation
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Pathways: DBH inhibition
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
Accumulation, Damaged mitochondrial DNA
Source: https://aopwiki.org/
Accelerated, Aging
Source: https://aopwiki.org/
Overwhelmed, Mitochondrial DNA repair mechanisms
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Increase, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Increased, Appetite and hunger
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
impaired, Development
Source: https://aopwiki.org/
Decreased, Glucose oxidase enzyme activity
Source: https://aopwiki.org/
Decreased, Hydrogen peroxide production
Source: https://aopwiki.org/
Reduced, Antiseptic incorporated in food
Source: https://aopwiki.org/
Reduced, Food storage
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
N/A, hypoxia
Source: https://aopwiki.org/
Increased, amputations
Source: https://aopwiki.org/
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
Source: https://aopwiki.org/
modulation, sodium channel
Source: https://aopwiki.org/
prolonged, Depolarization of neuronal membrane
Source: https://aopwiki.org/
Overactivation, Neuronotransmitter release
Source: https://aopwiki.org/
Overactivation, muscle contraction
Source: https://aopwiki.org/
Increased, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Increased, muscular waves in foot
Source: https://aopwiki.org/
Increased, water retention in foot
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Depletion, energy reserves
Source: https://aopwiki.org/
Increased, foot detachment
Source: https://aopwiki.org/
Increased, locomotion
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increase, predation
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decreased, anxiety
Source: https://aopwiki.org/
Decreased, sheltering
Source: https://aopwiki.org/
Antagonism, Histamine Receptor (H2)
Source: https://aopwiki.org/
Decrease, histaminergic neuron excitation
Source: https://aopwiki.org/
N/A, sedation
Source: https://aopwiki.org/
Decreased, locomotion
Source: https://aopwiki.org/
impaired, Learning and memory
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Reduced, Spawning behavior
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Pheromone release
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Meiotic prophase I/metaphase I transition, oocyte
Source: https://aopwiki.org/
Increased, cyclic adenosine monophosphate
Source: https://aopwiki.org/
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
Source: https://aopwiki.org/
Increased, Chromosome misseggregation
Source: https://aopwiki.org/
impaired, ion channels
Source: https://aopwiki.org/
Altered, Action Potential
Source: https://aopwiki.org/
Increased, cardiac arrthymia
Source: https://aopwiki.org/
Increased, Binding of chemicals to 2u (serum)
Source: https://aopwiki.org/
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (renal tubular cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Binding, Tubulin
Source: https://aopwiki.org/
Depolymerization, Microtubule
Source: https://aopwiki.org/
Disorganization, Spindle
Source: https://aopwiki.org/
Altered, Meiotic chromosome dynamics
Source: https://aopwiki.org/
Altered, Chromosome number
Source: https://aopwiki.org/
Increase, Aneuploid offspring
Source: https://aopwiki.org/
Activation, Constitutive androstane receptor
Source: https://aopwiki.org/
Altered gene expression specific to CAR activation, Hepatocytes
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increased, Induction of pyruvate dehydrogenase (PDH)
Source: https://aopwiki.org/
Increase, Oxidative metabolism
Source: https://aopwiki.org/
Increase, Cytotoxicity (club cells)
Source: https://aopwiki.org/
Increase, Necrosis (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (bronchioloalveolar)
Source: https://aopwiki.org/
Decreased, Uptake of inorganic iodide
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Decreased, Androgen receptor activity
Source: https://aopwiki.org/
Decreased, Testosterone binding to androgen receptor (hypothalamus)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increased, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Dopaminergic activity
Source: https://aopwiki.org/
Decreased, Prolactin
Source: https://aopwiki.org/
Increased, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Decreased, Progesterone from corpus luteum
Source: https://aopwiki.org/
Increase, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increase, Endometrial adenocarcinomas
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channel
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
N/A, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Decreased, population 1
Source: https://aopwiki.org/
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
Source: https://aopwiki.org/
Increased, Plasma tyrosine
Source: https://aopwiki.org/
Increase, Cytotoxicity (corneal cells)
Source: https://aopwiki.org/
Increase, Inflammation (corneal cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (corneal cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (tubular epithelial cells)
Source: https://aopwiki.org/
Activation, Androgen receptor
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Cytotoxicity (hepatocytes)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Decrease, Incorporation of active iodide into iodotyrosines
Source: https://aopwiki.org/
Inhibition, 5α-reductase activity
Source: https://aopwiki.org/
Increased, Leutinizing hormone (LH)
Source: https://aopwiki.org/
Decrease, Bioactivation of testosterone
Source: https://aopwiki.org/
Increase, Urinary bladder calculi
Source: https://aopwiki.org/
Increase, Cytotoxicity (urothelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (urothelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (urothelial)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (urothelial)
Source: https://aopwiki.org/
Inhibition, Prolyl hydroxylases
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
modulation, Unknown
Source: https://aopwiki.org/
Increased, HIF-1 alpha transcription
Source: https://aopwiki.org/
Inhibition, HMG-CoA reductase
Source: https://aopwiki.org/
Decreased, mevalonate
Source: https://aopwiki.org/
Decreased, cholesterol
Source: https://aopwiki.org/
Decreased, Testosterone
Source: https://aopwiki.org/
malformed, Male reproductive tract
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Inhibition, Antgonism of NE receptor
Source: https://aopwiki.org/
Decreased, Binding of NE to NE receptors on GnRH neurons
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Glomerular filtration
Source: https://aopwiki.org/
Decreased, Renal plasma flow
Source: https://aopwiki.org/
Decreased, Sodium reabsorption
Source: https://aopwiki.org/
Increased, Serum creatinine
Source: https://aopwiki.org/
Occurrence, Cystic dilatation (renal tubule)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (podocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Renal tubule)
Source: https://aopwiki.org/
Decreased, Renal ability to dilute urine
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Inhibition, Phospholipase A
Source: https://aopwiki.org/
Damage, Lipid bilayer
Source: https://aopwiki.org/
Disturbance, Lysosomal function
Source: https://aopwiki.org/
Injury, Mitochondria
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Ballooning degeneration (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (kupffer cell)
Source: https://aopwiki.org/
Induction, Microvesicular fat
Source: https://aopwiki.org/
Formation, Mallory body
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Bile duct cell)
Source: https://aopwiki.org/
Formation, Liver fibrosis
Source: https://aopwiki.org/
Oxidation, Uroporphyrinogen
Source: https://aopwiki.org/
Inhibition, UROD
Source: https://aopwiki.org/
Accumulation, Highly carboxylated porphyrins
Source: https://aopwiki.org/
Induction, CYP1A2/CYP1A5
Source: https://aopwiki.org/
Uroporphyria
Source: https://aopwiki.org/
Decrease, Intracellular pH
Source: https://aopwiki.org/
Increase, Tissue Degeneration, Necrosis & Atrophy
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Respiratory or Squamous Metaplasia
Source: https://aopwiki.org/
Increase, Mutations in Critical Genes
Source: https://aopwiki.org/
Increase, Site of Contact Nasal Tumors
Source: https://aopwiki.org/
Inhibition, organic anion transporter 1 (OAT1)
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Increased, blood potassium concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Increased, Oxidative Stress
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increase, Cancer
Source: https://aopwiki.org/
Disruption, Lysosome
Source: https://aopwiki.org/
Infiltration, Inflammatory cells
Source: https://aopwiki.org/
Inflammation, Liver
Source: https://aopwiki.org/
Activation, EGFR
Source: https://aopwiki.org/
Occurrence, Transdifferentiation of ciliated epithelial cells
Source: https://aopwiki.org/
Occurrence, Metaplasia of goblet cells
Source: https://aopwiki.org/
Occurrence, Hyperplasia of goblet cells
Source: https://aopwiki.org/
Increase, Proliferation of goblet cells
Source: https://aopwiki.org/
Activation, SP1
Source: https://aopwiki.org/
Decrease, Apoptosis of ciliated epithelial cells
Source: https://aopwiki.org/
Increase, Mucin production
Source: https://aopwiki.org/
Chronic, Mucus hypersecretion
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Oxidation, Glutathione
Pathways: Hypertension
Source: https://aopwiki.org/
S-Glutathionylation, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
Decrease, GTPCH-1
Pathways: Hypertension
Source: https://aopwiki.org/
Decrease, Tetrahydrobiopterin
Pathways: Hypertension
Source: https://aopwiki.org/
Uncoupling, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
Depletion, Nitric Oxide
Pathways: Hypertension
Source: https://aopwiki.org/
impaired, Vasodilation
Pathways: Hypertension
Source: https://aopwiki.org/
Increase, Vascular Resistance
Pathways: Hypertension
Source: https://aopwiki.org/
Decrease, Akt/eNOS activity
Pathways: Hypertension
Source: https://aopwiki.org/
Hypertension
Pathways: Hypertension
Source: https://aopwiki.org/
reduced dimerization, ARNT/HIF1-alpha
Source: https://aopwiki.org/
Increase, Pericardial edema
Source: https://aopwiki.org/
reduced production, VEGF
Source: https://aopwiki.org/
Increase, Embryolethality
Source: https://aopwiki.org/
Binding, Transthyretin in serum
Source: https://aopwiki.org/
Displacement, Serum thyroxine (T4) from transthyretin
Source: https://aopwiki.org/
Increased, Free serum thyroxine (T4)
Source: https://aopwiki.org/
Increased, Uptake of thyroxine into tissue
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from tissues
Source: https://aopwiki.org/
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
Source: https://aopwiki.org/
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells
Source: https://aopwiki.org/
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation
Source: https://aopwiki.org/
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus
Source: https://aopwiki.org/
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response
Source: https://aopwiki.org/
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
Source: https://aopwiki.org/
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs
Source: https://aopwiki.org/
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Binding, Immunophilins
Source: https://aopwiki.org/
Inhibition, Calcineurin Activity
Source: https://aopwiki.org/
Interference, nuclear localization of NFAT
Source: https://aopwiki.org/
Reduction, NFAT complex formation
Source: https://aopwiki.org/
Suppression, IL-2 and IL-4 production
Source: https://aopwiki.org/
Suppression, Suppression of production of cytotoxic T-cells
Source: https://aopwiki.org/
Suppression, Suppression of T-cell dependent antibody production
Source: https://aopwiki.org/
Impairment, T-cell dependent antibody response
Source: https://aopwiki.org/
Relief, Relief of atopic dermatitis
Source: https://aopwiki.org/
Increase, Increased susceptibility to infection
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Activation, ionotropic GABA Receptor chloride channel
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Induction, Somatic muscle paralysis
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channels
Source: https://aopwiki.org/
Induction, pharyngeal muscle paralysis
Source: https://aopwiki.org/
Increased, induction of UDPGT's in liver
Source: https://aopwiki.org/
Increased, T4/T3 catabolism
Source: https://aopwiki.org/
Decreased, serum T4/T3
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increased, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increased Apoptosis, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
Increased, adipogenesis
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, proliferation of mesenchymal cells
Source: https://aopwiki.org/
Increased, IGF-1 (mouse)
Source: https://aopwiki.org/
Increased, Firbrosarcoma
Source: https://aopwiki.org/
Increased, liposarcoma
Source: https://aopwiki.org/
Increased, hemagiosarcoma
Source: https://aopwiki.org/
Activation, beta-2 adrenergic receptor
Source: https://aopwiki.org/
Increased activity, beta-2 adrenergic receptor
Source: https://aopwiki.org/
relaxation, smooth muscle
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, smooth muscle
Source: https://aopwiki.org/
Hypertrophy/hyperplasia, smooth muscle
Source: https://aopwiki.org/
Promotion, mesovarian leiomyomas
Source: https://aopwiki.org/
Decreased, Ovarian E2
Source: https://aopwiki.org/
Suppression, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Increased, secretion of GnRH from hypothalamus
Source: https://aopwiki.org/
Increased, secrection of FSH from anterior pituitary
Source: https://aopwiki.org/
Increased, secretion of LH from anterior pituitary
Source: https://aopwiki.org/
Hyperplasia, ovarian stromal cells
Source: https://aopwiki.org/
Hyperplasia, ovarian epithelium
Source: https://aopwiki.org/
Decrease, E2 blood concentrations at hypothalamus
Source: https://aopwiki.org/
Promotion, ovarian adenomas
Source: https://aopwiki.org/
Promotion, ovarian granular cell tumors
Source: https://aopwiki.org/
Increased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, bile flow
Source: https://aopwiki.org/
Increased, cholestasis
Source: https://aopwiki.org/
Alteration, lipid metabolism
Source: https://aopwiki.org/
prolonged, elevation of serun CCK
Source: https://aopwiki.org/
Increased, Cellular proliferation / hyperplasia of acinar cells
Source: https://aopwiki.org/
Increased, Pancreatic acinar tumors
Source: https://aopwiki.org/
prepubertal increase, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Promotion, SIX-1 postive basal-type progenitor cells
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, aberrant basal cells
Source: https://aopwiki.org/
squamous metaplasia, aberrant basal cells
Source: https://aopwiki.org/
Increased, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increased, adenosquamous carcinomas of endometrium
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, prolactin exposure
Source: https://aopwiki.org/
Hyperplasia, Mammary gland
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, lactotroph hyperplasia and hypertrophy
Source: https://aopwiki.org/
Increased, adenomas (pituitary)
Source: https://aopwiki.org/
Decreased, Dopaminergic activity
Source: https://aopwiki.org/
Increased, prolactin secretion
Source: https://aopwiki.org/
Increased, hyperplasia (mammary gland)
Source: https://aopwiki.org/
persistent, cytotoxicity (pleura or peritoneum)
Source: https://aopwiki.org/
Increased, inflammation
Source: https://aopwiki.org/
Increased, Cell Proliferation (mesothelium)
Source: https://aopwiki.org/
Increased, mesotheliomas
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase 1 activity
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Occurrence, renal ischemia
Source: https://aopwiki.org/
Increased, Deformed Wing Virus levels
Source: https://aopwiki.org/
Increased, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Unknown, MIE
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
Source: https://aopwiki.org/
Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
Source: https://aopwiki.org/
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
Source: https://aopwiki.org/
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
Source: https://aopwiki.org/
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
Source: https://aopwiki.org/
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
Source: https://aopwiki.org/
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
Source: https://aopwiki.org/
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
Source: https://aopwiki.org/
Osteoporosis and vascular calcification, Bone deterioration
Source: https://aopwiki.org/
Impaired recruitment , Population trajectory
Source: https://aopwiki.org/
Inhibition, Iodotyrosine deiodinase (IYD)
Source: https://aopwiki.org/
Inhibition, Deiodinase 3
Source: https://aopwiki.org/
Increased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Inhibition, Pendrin
Source: https://aopwiki.org/
Inhibition, Dual oxidase
Source: https://aopwiki.org/
Activation, Hepatic nuclear receptor(s)
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, oocyte maturation
Source: https://aopwiki.org/
induced spawning
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
TRPA1 activation, TRPA1 Receptor
Source: https://aopwiki.org/
TRPV1 activation, TRPV1
Source: https://aopwiki.org/
Activation of oxidative stress pathway
Source: https://aopwiki.org/
Opening of calcium channel, Calcium influx
Source: https://aopwiki.org/
Excitation, Neuron nerve ending excitation
Source: https://aopwiki.org/
SP (Substance P) release, Local increase of SP
Source: https://aopwiki.org/
Non-neuronal production of TNF, Epithelial irritation
Source: https://aopwiki.org/
Immune system inflammation
Source: https://aopwiki.org/
Production of nerve growth factor , Epithelial irritation
Source: https://aopwiki.org/
Non-neuronal production of IL-8/CXCL1, Epithelial irritation
Source: https://aopwiki.org/
Generation of novel epitopes , Antigen presentation
Source: https://aopwiki.org/
Trigeminal and/or vagal nerve excitation
Source: https://aopwiki.org/
Chronic Cough, Respiratory irritability
Source: https://aopwiki.org/
Sensitization, Immune system
Source: https://aopwiki.org/
Decreased, sodium conductance 2
Source: https://aopwiki.org/
Decreased, GABA release
Source: https://aopwiki.org/
Activation, Estrogen receptor
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Decreased, Apoptosis (Epithelial Cells)
Source: https://aopwiki.org/
Increased, ER binding to DNA (classical pathway)
Source: https://aopwiki.org/
Increased, ER binding to T.F. to DNA (non-classical pathway)
Source: https://aopwiki.org/
Increased, Proliferation (Endothelial cells)
Source: https://aopwiki.org/
Increased, Migration (Endothelial Cells)
Source: https://aopwiki.org/
Increased, Non-genomic signaling
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
modulation, Extracellular Matrix Composition
Source: https://aopwiki.org/
Increased, Invasion
Source: https://aopwiki.org/
Activation, Fibroblasts
Source: https://aopwiki.org/
Activation, Macrophages
Source: https://aopwiki.org/
Increased, Angiogenesis
Source: https://aopwiki.org/
Altered, Gene Expression
Source: https://aopwiki.org/