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OECD User Handbook

Wiki authors please refer to the OECD Users' Handbook when developing your AOP. If you notice any bugs, please report them .

Commenting on AOPs

To avoid spammers, we now require email confirmation before any user is allowed to edit. We apologize for any inconvenience this may cause. Instructions for confirming your email if you already have an account are given here: Confirm Email. If you have any troubles confirming your email, please email us at Before commenting on AOPs, please read the AOP Wiki Editing & Comments Policy. Additional guidance for commenting is available here: Commenter Information.

Welcome to the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki)

If you are interested in contributing AOP-related knowledge to the AOP-KB, please follow the instructions laid out at the OECD Adverse Outcome Pathways, Molecular Screening and Toxicogenomics page. The Guidance on Developing and Assessing AOPs document is the basis for all work related to contributing and sharing AOP-related knowledge. A Users' Handbook Supplement to this Guidance has been written to aid systematic development and transparent assessment of Adverse Outcome Pathways (AOPs). The handbook contains a template to guide AOP description and provides focused and practical instructions for developers and assessors intended to assist in identifying, organizing, and evaluating critical information on key events and linkages (i.e., key event relationships (KER)) within the AOP, as well as guidance on how to assess the weight of evidence supporting the overall AOP.


This wiki represents a joint effort between the European Commission – DG Joint Research Centre (JRC) and U.S. Environmental Protection Agency (EPA). This serves as one component of a larger OECD-sponsored AOP Knowledgebase effort and represents the central repository for all AOPs developed as part of the OECD AOP Development Effort by the Extended Advisory Group on Molecular Screening and Toxicogenomics. The other major components of this knowledgebase are Effectopedia, produced by the Organisation for Economic Co-operation and Development (OECD), the AOP Xplorer, produced by the US Army Corps of Engineers - Engineering Research and Development Center, and the Intermediate Effects DB produced by the JRC.

This wiki is based upon the Chemical Mode of Action wiki developed by the EPA under the auspices of the WHO International Programme on Chemical Safety (IPCS) Mode of Action Steering Group.


The content of this wiki is the sole responsibility of the individual contributors and does not necessarily represent the views of the Partner organizations. Mention of trade names or commercial products does not constitute endorsement by any of the Partner organizations.

How to add a new AOP

For more detailed instructions, please see the main Help page.

Before You Start

Please read the AOP Wiki Editing & Comments Policy.

General guidance on assembling AOP information in the AOP-Wiki is available in the OECD AOP Users' Handbook

Summary (for AOP) and Overview (all other pages) sections are intended for programmatic editing using the widgets in each subsection. If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets. If you need to make changes and can't determine how to do it through the widgets, contact us at, and we will help you make the necessary changes.

To create a new AOP

  1. Click the following link in the Sidebar: Create new AOP
  2. You may be prompted to sign in. If so, use your Wiki credentials to sign in. If not, proceed to the next step.
  3. In the text field labeled Short Title, enter a unique name with fewer than 30 characters.
  4. In the text field labeled Long Title, you may enter a more descriptive name for your AOP.
  5. Once you have populated the text fields, click the 'Create AOP' button. You will be taken to the widget where you can add an MIE, KEs and an AO to the AOP.
    • If you have an MIE, the current naming convention would include both the MIE and AO in the AOP page name. If the MIE is unknown, use the earliest KE and we'll rename the page once the MIE is defined.
  6. When you are done adding your data to the widget, click on the 'Return to wiki' button at the top of the page.

To edit AOP wiki pages

  1. To add text to any section, click the 'edit' link to the right of the Heading for that section. Type your notes in the resulting text box, then click the 'Save Page' button at the bottom. Don't delete the ==Heading== line at the top. You shouldn't need to manually edit the 'Summary of the AOP' section. Please make those changes using the widget via the automated process described below.
  2. To add a new item in the Summary section (If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.):
    1. Click the 'widget page' link located directly under the 'Summary of the AOP' heading.
    2. You will be directed to the widget page for your AOP where there are buttons to add new items to each Summary section.
      1. Click the corresponding 'Add' button for whatever item you want to add to the summary.
      2. Fill out the appropriate boxes in the pop up window. Details for each are on the AOP Help page.
      3. Click the Submit button.
    3. When you add a new item in the widget page, the corresponding AOP page in the wiki is updated. This step is done automatically. There is no action to be undertaken on your part.
    4. When you add an item in the widget, a link to the item will appear in table under the 'Summary of the AOP' heading on the wiki page. You can view or edit information for the item by clicking on the link. Because these items are now connected, you can return to the AOP wiki page by clicking on the AOP link in the page's 'Overview' section. If you added an item that is new to the knowledge base, its wiki page will need to be populated.
  3. In cases where a heading does not have a widget yet, check out our Upcoming Features page to see where it stands in the queue. New buttons will be added as the widgets are developed.

To edit other wiki pages (key events, MIE's, etc.)

  1. Overview sections are intended for editing through the widget to maintain a consistent format across pages. (If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.)
  2. All other sections can be edited using the methods described above for editing AOP wiki pages.